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Overexpression of the Parkinson-related protein, α-synuclein, leads to blood-brain barrier leakage and pericyte activation in mice. A study published in Scientific Reports identifies pericytes as potential target cells for early interventions. Parkinson’s disease is a movement disorder caused by the accumulation and aggregation of α-synuclein and degeneration of dopaminergic neurons. Disruption of
Researchers from Lund Stem Cell Center highlight the importance of controlling viral elements that reside in the genome and how their activation during development may contribute to brain disorders later in life. Around 10% of the human genome is composed of DNA sequences originating from viruses that infected our ancestors throughout the millions of years of our evolution. Under normal conditions
https://www.multipark.lu.se/article/activation-ancient-viruses-during-brain-development-causes-inflammation - 2025-11-21
During her PhD studies Shelby Shrigley has been exploring patient-specific cell replacement therapy for Parkinson's disease. Defending her PhD thesis on March 12th, here Shelby tells us about her research within the Developmental and Regenerative Neurobiology research group led by Prof. Malin Parmar and her time spent at Lund Stem Cell Center. Can you tell us about your PhD research? The main focu
https://www.multipark.lu.se/article/phd-defence-interview-shelby-shrigley - 2025-11-21
Alzheimer’s disease seems to progress faster in women than in men. The protein tau accumulates at a higher rate in women, according to research from Lund University in Sweden. The study was recently published in Brain. Over 30 million people suffer from Alzheimer’s disease worldwide, making it the most common form of dementia. Tau and beta-amyloid are two proteins known to aggregate and accumulate
https://www.multipark.lu.se/article/women-accumulate-alzheimers-related-protein-faster - 2025-11-21
In a collaborative study, with other European research groups, scientists from Lund University in Sweden have shed new light on how the protein aggregates that accumulate in the Parkinsonian brain may contribute to neuronal injury during disease progression. The study is published in Cell Reports. The brain is a complex organ composed of billions of neurons, whose proper function is dependent on a
https://www.multipark.lu.se/article/new-insights-toxic-protein-aggregate-formation-parkinsons-disease-size-matters - 2025-11-21
On the last of December, Professor Gunnar Gouras left his position as a coordinator for MultiPark after five years. Here is how he sums up his time and mission for our environment. Can you describe your time as a coordinator for Multipark? To lead Multipark has been very interesting as well as challenging. To have the support from the Swedish government to invest in excellent research is fantastic
https://www.multipark.lu.se/article/interview-gunnar-gouras-about-his-time-coordinator - 2025-11-21
Congratulations to Prof. Malin Parmar, who has been elected as one of three new members of the Board of Directors at the International Society for Stem Cell Research (ISSCR). The Developmental and Regenerative Neurobiology research group led by Prof. Parmar aims to develop new, cell-based therapies for neurodegenerative diseases. Together with her team, Prof. Parmar has shown in a series of pionee
https://www.multipark.lu.se/article/malin-parmar-elected-isscr-board-directors - 2025-11-21
Alzheimer's disease is characterized by the abnormal accumulation and spread of the tau protein in the brain. An international study can now show how tau spreads according to four distinct patterns that lead to different symptoms with different prognoses of the affected individuals. The study was published in Nature Medicine. “In contrast to how we have so far interpreted the spread of tau in the
https://www.multipark.lu.se/article/alzheimers-disease-composed-four-distinct-subtypes - 2025-11-21
On May 11, it is time for the first of a total of six workshops concerning the strategic research areas’ (SRA) work on sustainable development. Sustainability is more than climate and environmental issues. Goal number 3 of the UN global sustainability goals focuses on “good health and well-being”. The workshop series are arranged by the SRA Collegium and Sustainability forum. Within the health-rel
https://www.multipark.lu.se/article/workshop-series-sustainability-effect-research - 2025-11-21
Deep interviews with patients who are at an early stage of Parkinson’s disease show that acceptance was a prerequisite for a maintained life satisfaction despite the disease. The study was conducted by health science researchers from the strategic research area MultiPark at Lund University. People living with Parkinson's disease deal with symptoms and impairments due to the progression of the dise
https://www.multipark.lu.se/article/acceptance-key-life-satisfaction-persons-parkinsons-disease - 2025-11-21
Nine senior researchers from five different faculties at Lund University have been granted three million SEK for a novel transdisciplinary initiative to improve the early diagnosis of Alzheimer’s disease. Four of them are research leaders from the strategic research area MultiPark at the Medical Faculty. The collaboration also involves Region Skåne, Lund Municipality, and several important partner
Researchers at Lund University in Sweden have developed an algorithm that combines data from a simple blood test and brief memory tests, to predict with great accuracy who will develop Alzheimer's disease in the future. The findings are published in Nature Medicine. Approximately 20-30% of patients with Alzheimer's disease are wrongly diagnosed within specialist healthcare, and diagnostic work-up
https://www.multipark.lu.se/article/simple-diagnostic-tool-predicts-individual-risk-alzheimers - 2025-11-21
During her Ph.D. studies, Yiyi Yang has been investigating the role of microglia in the pathological development of Alzheimer’s disease. On the 3rd of June, it is time to defend her work supervised by Prof. Tomas Deierborg. Now, Yiyi tells us about her research in the Experimental Neuroinflammation Laboratory as being a part of MultiPark. Can you tell us about your Ph.D. research? The focus of our
https://www.multipark.lu.se/article/phd-defence-interview-yiyi-yang - 2025-11-21
Around 20 000 Swedes are currently suffering from Parkinson’s disease, yet there are still only treatments to alleviate symptoms. Through a new biobank, researchers gain access to the genetic profiles of 1000 Parkinson’s patients together with comprehensive information about their lifestyles and medical histories. “I am convinced that many researchers will use the biobank over the next few years,
https://www.multipark.lu.se/article/new-biobank-provides-insights-parkinsons-disease - 2025-11-21
On the first of January, Professor Angela Cenci Nilsson took on as the new coordinator for MultiPark. Now she tells us about her visions for our network and about being a senior researcher in the environment. About the role as the new coordinator I will do my best to foster collaborative projects with high scientific and/or translational potential. What does being appointed to the new coordina
https://www.multipark.lu.se/article/interview-angela-cenci-nilsson-about-being-new-coordinator-multipark - 2025-11-21
T-cells, antibodies, and antigens. During the past year, we have learned a lot about our immune system through media. Most people agree that the immune system is crucial for our survival. But how does the immune system affect Parkinson’s disease; is it necessary to keep our brains healthy, or does it contribute to disease progression? The answer to that question is unfortunately not straightforwar
https://www.multipark.lu.se/article/does-our-immune-response-affect-risk-developing-parkinsons-disease - 2025-11-21
An experimental study from Lund University in Sweden has revealed that the Alzheimer’s protein amyloid-beta accumulates inside nerve cells, and that the misfolded protein may then spread from cell to cell via nerve fibres. This happens at an earlier stage than the formation of amyloid-beta plaques in the brain, something that is associated with the progression of Alzheimer’s disease. The study in
https://www.multipark.lu.se/article/does-alzheimers-disease-start-inside-nerve-cells - 2025-11-21
A large collaborative project focused on understanding and treating dysfunctions of cortico-basal ganglia circuits in Parkinson´s disease (PD) has been awarded 35 million DKK from the Lundbeck Foundation. Angela Cenci Nilsson, coordinator of MultiPark, leads one of the three included research teams. Her group, the Basal ganglia pathophysiology, will conduct studies in animal models providing a bas
https://www.multipark.lu.se/article/new-transnational-collaboration-target-circuit-dysfunctions-parkinsons-disease - 2025-11-21
A combination of two imaging methods can be used to achieve structural and chemical information within a single neuron. Researchers from MultiPark at Lund University recently developed this approach. Their study reveals that amyloid aggregates, implicated in Alzheimer’s disease, may cause clustering of iron in primary neurons. Alzheimer's disease is a major cause of dementia. Understanding where a
Amyloid-beta accumulation may start inside neurons. A novel imaging approach to study structural changes before amyloid plaques are formed. Four distinct subtypes of Alzheimer's disease. A simple diagnostic tool predicting the risk of developing the disease. And a collaboration with Region Skåne, Lund Municipality, and the pharma industry to facilitate earlier diagnosis and more accurate prognosti
https://www.multipark.lu.se/article/alzheimers-awareness-month-five-optimistic-research-news-multipark - 2025-11-21
